Dr. Jake Y. Chen is a professor and Chief Bioinformatics Officer of the newly established Informatics Institute at the University of Alabama at Birmingham (UAB). He was invited by the CBRC to present his seminar, entitled Translational Informatics: Developing Tools to Model Human Genomics Big Data Towards Medicine 2.0. Dr. Chen discusses his approach to bridging the gap between genomics data and human disease complexity, using systems biology modeling techniques. In particular, he will describe how gene signature and pathway modules are built, from which multiscale network models are constructed.