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Statistics Seminar: Statistical Inference through Linear Relationships, with Applications to Imaging Genetics

Start Date: March 13, 2018
End Date: March 13, 2018

By Professor Zhaoxia Yu, Associate professor at University of California, Irvine
Data collected in many scientific areas are inherently high-dimensional and multi-way. While such data provides an excellent opportunity for us to conduct an integrative analysis of multiple data modalities, it is challenging to model associations between sets of massive, complexly structured, and high-dimensional data. Motivated by applications to neuroimaging and genetics data, we propose to evaluate the association between two domains of variables by using an adaptive Mantel test. In this approach, the overall association is summarized by the linear relationship of similarity of all pairs of subjects between two observational domains, where our definition of similarity involves a data driven tuning parameter. We then illustrate how our approach links two classical regression methods (fixed-effect and random-effect linear models) and its connection with various measures of “variance explained”. The performance of the adaptive Mantel test is evaluated on simulated data, and is used to investigate associations between genetic markers related to Alzheimer's Disease and healthy brain physiology with data from a working memory study of 350 college students from Beijing Normal University.
Biography: Zhaoxia Yu is an associate professor of statistics at University of California, Irvine. She obtained her master and Ph.D. degrees in statistics from University of California, Davis and Rice University, respectively. After her two year postdoctoral training at Mayo Clinic, she joined the Department of Statistics at University of California, Irvine in 2007. Her general research interest is to develop and apply statistical methods to different areas, such as genetic, medical, and neurology studies. When she has free time, she enjoys jogging.

More Information:

For more info contact: Prof. Hernando Ombao: email:
Date: Tuesday 13th Mar 2018
Time:04:00 PM - 05:00 PM
Location: Building 1, Level 4, room# 4102
Refreshments: Light refreshments will be served around 3:30 Pm