Symbolic AI in Computational Biology: Applications to Disease Gene and Drug Target Identification
The University of Cambridge in the United Kingdom
Overview
Abstract
KAUST Assistant Professor Robert Hoehndorf will give a seminar on "Symbolic AI in Computational Biology: Applications to Disease Gene and Drug Target Identification" at the University of Cambridge in the United Kingdom.
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The life sciences have invested significant resources in the development and application of semantic technologies to make research data accessible and interlinked, and to enable the integration and analysis of data. Utilizing the semantics associated with research data in data analysis approaches is often challenging. Now, novel methods are becoming available that combine symbolic methods and statistical methods in Artificial Intelligence. In my talk, I will describe how to apply knowledge graph embeddings for analysis of biological and biomedical data, in particular, identification of gene-disease associations and drug targets. I will also show how information from text-mining can be combined in a multi-modal machine learning model to further improve the predictive performance of these models, and how these methods can help to improve interpretation of causative genomic variants in personal genomic sequence data.
