Simulating evolution to understand a hidden switch

Using computer simulations built on reasonable assumptions and conducted under careful control, computational bioscientists can mimic real biological conditions. Starting with the original founding population (ancient phase), they can evolve the population over several thousand generations to develop an intermediate phase, and then evolve that generation another several thousand generations to develop a derived phase.

© 2021 KAUST; Anastasia Serin

Computer simulations of cells evolving over tens of thousands of generations reveal why some organisms retain a disused switch mechanism that turns on under severe stress, changing some of their characteristics. Maintaining this “hidden” switch is one means for organisms to maintain a high degree of gene expression stability under normal conditions.

Tomato hornworm larvae are green in warmer regions, making camouflage easier, but black in cooler temperatures so that they can absorb more sunlight. This phenomenon, found in some organisms, is called phenotypic switching. Normally hidden, this switching is activated in response to dangerous genetic or environmental changes.

Scientists have typically studied this process by investigating the changes undergone by organisms under different circumstances over many generations. Several years ago, for example, a team bred generations of tobacco hornworm larvae to observe and induce color changes similar to those that occurred in their tomato hornworm relatives.

“Computer simulations, when built on reasonable assumptions and conducted under careful control, are a very powerful tool to mimic the real situation,” says KAUST computational bioscientist Xin Gao. “This helps scientists observe and understand principles that are otherwise very difficult, or impossible, to observe by wet-lab experiments.”

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