A new and powerful approach for analyzing seizures in epilepsy patients has been developed using electroencephalogram (EEG) records of brainwave patterns. The method holds promise for better understanding the mechanisms of seizures.
“Despite being a well-studied neuronal disorder, predicting an epileptic seizure event remains difficult,” says Matheus Guerrero, a Ph.D. student who led the study. “This work is the first attempt to understand the epileptic seizure process from the vantage point of extreme value theory – a field of statistics dealing with large deviations from the median of probability distributions.”
As Guerrero explains, the brain is permeated by electric fields generated by neuronal activity. When a seizure occurs, there is a sudden and uncontrolled disturbance of these electrical patterns. Working with Raphaël Huser from the Extreme Statistics Group and Hernando Ombao from the Biostatistics Group, Guerrero’s study focused on whether extreme value theory could be used to better understand seizure events from EEG records.
“Current statistical methods for analyzing EEGs consider the oscillatory and cross-dependence patterns in the entire distribution of brainwaves,” Guerrero says. “However, these methods completely neglect the specific patterns that might occur in the tails of the distributions, which is where relatively rare extreme events like seizures occur.”
The team was specifically looking for cross-interactions in brainwave patterns between different areas of the brain during seizure events, which are expected to differ significantly from those during nonseizure periods. Conventional statistical methods are unable to differentiate between dependence and independence in the tail versus the overall probability distribution, meaning they might miss potentially important seizure-specific connections among unexpected brain regions.
“We concentrated our attention on damaged areas of the brain with high EEG amplitudes,” says Guerrero. “Using this approach, we were able to model brain connectivity in the extremal setting of a seizure event.”
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