biology

AI4GH Seminar Series | Predicting Protein Function and Phenotype Associations

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B2 R5220

The amount of available protein sequences is rapidly increasing, mainly as a consequence of the development and application of high ​throughput sequencing technologies in the life sciences.

Genetic Algorithms for Optimization of Machine-learning Models and their Applications in Bioinformatics

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B3 L5 R5209

Abstract ​​​Machine-learning (ML) techniques have been widely applied to solve different problems in biology. However, biological data are large and complex, which often results in extremely intricate ML models. Frequently, these models may have poor performance or may be computationally unfeasible. This study presents a set of novel computational methods and focuses on the application of genetic algorithms (GAs) for the simplification and optimization of ML models and their applications to biological problems. The dissertation addresses the following three challenges. The first challenge is

AI4GH Seminar Series| Artificial Intelligence for Genomics and Health: Introduction and Overview

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B2 R5220

Abstract Genomics and health are prime areas for the development and application of novel intelligent algorithms due to a large amount of available research data, the high complexity of the problem, and the significant social and economic benefits of improving health outcomes in humans. In the past, genomics and health have been one of the key drivers in the development of Artificial Intelligence methods, including machine learning, expert systems, or graph-based algorithms. I will introduce the new seminar series on Artificial Intelligence for Genomics and Health (AI4GH), and then discuss our

Peak performance for proteins

1 min read ·
An improved peak fitting procedure enables a better determination of protein structures.

Disease researchers have a way with words

1 min read ·
Specialized word search method sheds light on phenotypic similarity of diseases.

The awesome scope of big data

1 min read ·
Sifting through huge amounts of data may bring a better understanding of whale shark social structures, protein targets for drug therapies and disease-causing genes.

PhD Dissertation Defense | Prioritizing Causative Genomic Variants by Integrating Molecular and Functional Annotations from Multiple Biomedical Ontologies

1 min read ·
CBRC PhD Student Azza Althagafi successfully defends her dissertation under the supervision of Associate Professor Robert Hoehndorf. She has been a member of the Bio-Ontology Research Group (BORG) since 2016. Her research interest lies in the crossroads of computer science and biology, leveraging AI techniques to explore the human genome's intricacies and its link to various diseases.

Ivan Viola

Professor, Computer Science
Professor Viola’s expertise lies in scientific visualization and visual computing. His research focuses on multiscale visualization and modeling of complex biological systems, ranging from cellular organisms to atomistic-level details.