Research in the Structural Biology & Engineering Laboratory is dedicated to elucidating the molecular basis of the function and (de)regulation of proteins central to cellular key signaling networks in plants, and animals. Investigations are based on an integrated structural biology approach that combines functional and structural data from multiple sources (small angle X-ray scattering, X-ray crystallography, NMR, cryo-EM, computational methods, biochemistry, ligand binding assays and functional analyses). Results are translated to engineer molecules with desired properties (e.g. reporters or inhibitors). Structural biology approaches are also used to enhance computational methods for functional annotation of genes (system-wide or focused).
The Laboratory has several state of the art facilities and equipment’s. Some of them are listed below:
ÄKTA pure protein purification system
Flexible and intuitive chromatography system for purification in research applications. Read more...
Freedom EVO-200
Liquid handling and robotics workstation used for research and diagnostics. Read more..
Continuous Flow Cell Disrupter
High pressure cell disruption equipment used for protein characterisation and functional studies of cellular processes. Read more...
Monolith NT.115
System used to measure binding affinities in solution and Microscale Thermophorasis. Read more...
Biacore T200
Biacore T200 is a versatile system for high-quality characterization of molecular interactions, all the way from research to discovery and quality control. Read more...
For more information please visit Structural Biology and Engineering (StruBE) Lab website strube.kaust.edu.sa.